By Janos Fischer, C. Robin Ganellin, David P. Rotella
So much medications are analogue medications. There are not any normal principles how a brand new drug might be chanced on, however, there are a few observations which aid to discover a brand new drug, and likewise somebody tale of a drug discovery can begin and support new discoveries. quantity III is a continuation of the winning ebook sequence with new examples of validated and lately brought medicinal drugs.
the main a part of the ebook is written via key inventors both as a case research or a learn of an analogue type. With its wide variety throughout quite a few healing fields and chemical periods, this can be of curiosity to nearly each researcher in drug discovery and pharmaceutical chemistry, and -- including the former volumes -- constitutes the 1st systematic method of drug analogue development.Content:
Chapter 1 Pioneer and Analogue medicines (pages 1–19): Prof. Dr. Janos Fischer, Prof. Dr. C. Robin Ganellin and Prof. Dr. David P. Rotella
Chapter 2 festival within the Pharmaceutical Drug improvement (pages 21–35): Christian Tyrchan and Fabrizio Giordanetto
Chapter three Metabolic balance and Analogue?Based Drug Discovery (pages 37–75): Amit S. Kalgutkar and Antonia F. Stepan
Chapter four Use of Macrocycles in Drug layout Exemplified with Ulimorelin, a possible Ghrelin Agonist for Gastrointestinal Motility problems (pages 77–110): Dr. Mark L. Peterson, Dr. Hamid Hoveyda, Dr. Graeme Fraser, Eric Marsault and Rene Gagnon
Chapter five the invention of Anticancer medicinal drugs focusing on Epigenetic Enzymes (pages 111–139): A. Ganesan
Chapter 6 Thienopyridyl and Direct?Acting P2Y12 Receptor Antagonist Antiplatelet medicines (pages 141–164): Dr. Joseph A. Jakubowski and Atsuhiro Sugidachi
Chapter 7 Selective Estrogen Receptor Modulators (pages 165–185): Amarjit Luniwal, Rachael Jetson and Paul Erhardt
Chapter eight Discovery of Nonpeptide Vasopressin V2 Receptor Antagonists (pages 187–209): Kazumi Kondo and Hidenori Ogawa
Chapter nine the improvement of Cysteinyl Leukotriene Receptor Antagonists (pages 211–239): Peter R. Bernstein
Chapter 10 the invention of Dabigatran Etexilate (pages 241–267): Norbert Hauel, Andreas Clemens, Herbert Nar, Henning Priepke, Joanne van Ryn and Wolfgang Wienen
Chapter eleven the invention of Citalopram and Its Refinement to Escitalopram (pages 269–294): Klaus P. Bogeso and Connie Sanchez
Chapter 12 Tapentadol – From Morphine and Tramadol to the invention of Tapentadol (pages 295–318): Helmut Buschmann
Chapter thirteen Novel Taxanes: Cabazitaxel Case learn (pages 319–341): Dr. Herve Bouchard, Dr. Dorothee Semiond, Dr. Marie?Laure Risse and Dr. Patricia Vrignaud
Chapter 14 Discovery of Boceprevir and Narlaprevir: A Case learn for position of Structure?Based Drug layout (pages 343–363): Srikanth Venkatraman, Andrew Prongay and George F. Njoroge
Chapter 15 A New?Generation Uric Acid construction Inhibitor: Febuxostat (pages 365–376): Ken Okamoto, Shiro Kondo and Takeshi Nishino
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